Bioactive constituents of Anatolian Salvia species
Salvia Biotechnology, Springer International Publishing Ag, ss.31-132, 2018
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2018
- Doi Numarası: 10.1007/978-3-319-73900-7_2
- Yayınevi: Springer International Publishing Ag
- Sayfa Sayıları: ss.31-132
- Anahtar Kelimeler: Anatolia, Bioactivity, Flavonoid Phenolic, Lamiaceae, Salvia, Secondary metabolite, Sesquiterpenoid Diterpenoid, Sesterterpenoid, Steroid, Triterpenoid
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Salvia (sage) species are grown world-wide, mainly in the three regions; South-East Asia, South Europe to Central and South America with approximately 1000 species. The genus Salvia is represented by over 100 species in Turkey. Since ancient times, they have been used in folk medicine for many purposes in the world, for more than sixty different ailments ranging from aches to epilepsy, and to treat colds, bronchitis, tuberculosis, haemorrhage, some cardiovascular and menstrual disorders. In Anatolia, Salvia species are used against cold and flu, and in the treatment of stomach, liver and rheumatism problems and as wound healing agents. A literature survey and our experiences indicated that terpenoids and flavonoids are the main constituents of them. 45 Anatolian Salvia species have been investigated for their chemical constituents with some biological activities. Di-and triterpenoids were found to be the main non-volatile constituents besides flavonoids and phenolics. The aerial parts, particularly flowers and leaves of Anatolian Salvia species contain flavonoids, triterpenoids, and monoterpenes while diterpenoids are found mostly in the roots. Totally 317 compounds were isolated, major part belonging to diterpenoids, among isolated 158 diterpenoids from Anatolian Salvia species, almost 130 of which have abietane skeleton identified by spectroscopic methods, particularly based on extensive NMR and Mass techniques. In addition to diterpenoids, 60 triterpenoids, 15 steroids, 5 sesterterpenes and 9 sesquiterpenes and 41 flavonoids and 29 other phenolics were isolated. In this chapter, Anatolian Salvia plant extracts and/or its constituents with various biological activities were presented, including antioxidative, antimicrobial, anti-inflammatory, cytotoxic/ antitumor, cardiovascular, cholinesterase and some other enzymes inhibitory activities. In addition, some investigations on Salvia species consist of biological properties which carried out on the extracts rather than pure isolates were presented.