Is 5-fluorouracil-induced vasospasm a Kounis syndrome? A diagnostic challenge
Perfusion, cilt.26, sa.6, ss.542-545, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 6
- Basım Tarihi: 2011
- Doi Numarası: 10.1177/0267659111410347
- Dergi Adı: Perfusion
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.542-545
- Anahtar Kelimeler: Kounis syndrome, 5-fluorouracil, vasospasm, cardiotoxicity, antihistamine agents
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Cardiovascular hypersensitivity is a rare and well-documented side-effect of 5-FU (5-fluorouracil). Besides the common complications such as angina pectoris and myocardial infarction, it can also cause cardiogenic shock, and supraventricular and ventricular arrhythmias. Studies have reported that FU-induced angina most commonly occurred due to vasospasm. In our case, 9 hours after stopping the infusion of 5-FU, the patients developed symptoms and electrocardiographic (ECG) findings consistent with acute myocardial infarction. We intend to share this rare case and discuss whether this late complication after 5-FU infusion is an FU-induced vasospasm or rather an allergic reaction leading to Kounis syndrome. © 2011 SAGE Publications.