Association between the NAPLES score and malignant ventricular arrhythmias in cardiomyopathy patients
Future Cardiology, cilt.22, sa.8, ss.803-810, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 8
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/14796678.2026.2704395
- Dergi Adı: Future Cardiology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, MEDLINE, Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.803-810
- Anahtar Kelimeler: Cardiomyopathy, NAPLES score, malignant ventricular arrhythmia, ventricular tachycardia, ventricular fibrillation, cardiac implantable electronic device, inflammation, risk stratification
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Malignant ventricular arrhythmias are a major cause of sudden cardiac death in patients with cardiomyopathy. Traditional risk markers, including left ventricular ejection fraction, have limited ability to identify high-risk individuals. Objective: To investigate the association between the Naples Prognostic Score (NAPLES), a marker of inflammatory and nutritional status, and malignant ventricular arrhythmias in patients with cardiomyopathy and cardiac implantable electronic devices (CIEDs). Methods: This retrospective study included 299 patients with cardiomyopathy and CIEDs. The NAPLES score was calculated using serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Patients were classified into low (0–1) and high (2–4) NAPLES groups. Independent predictors were evaluated using multivariable logistic regression analysis. Results: Malignant ventricular arrhythmias were more common in patients with high NAPLES scores than in those with low scores (46.3% vs. 36.1%, p = 0.042). High NAPLES score was independently associated with malignant ventricular arrhythmias (OR: 2.00, 95% CI: 1.14–3.23, p = 0.027). Each one-point increase in NAPLES score was also associated with increased arrhythmic risk (OR: 1.40, 95% CI: 1.08–1.81, p = 0.018). Conclusion: The NAPLES score is independently associated with malignant ventricular arrhythmias and may aid arrhythmic risk stratification in patients with cardiomyopathy and CIEDs.