A 5-year multicenter clinical experience in local and locally advanced nasopharyngeal carcinoma from a non-endemic region: A retrospective cohort study
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.31, sa.2, ss.99-105, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.4999/uhod.214658
- Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.99-105
- Anahtar Kelimeler: Nasopharyngeal carcinoma, Survival, Prognosis, Clinical outcomes
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Nasopharyngeal carcinoma is an endemic disease in certain geographic regions. This study was undertaken to identify long-term outcome data and prognostic factors for current treatment options in a non-endemic area such as Turkey. One-hundred and thirty-two patients with local and locally advanced disease treated in three distinct oncology units in Turkey between 2010 and 2019 were retrospectively evaluated. Median duration of follow-up for OS was 68.9 months, respectively. A comparison of adjuvant and induction therapy for locally advanced (Stage 3 and 4a) disease showed a 5-year DFS of 85.5% vs. 76.4%, respectively (p= 0.360). The 5-year OS for adjuvant and induction therapy were 86.4% vs. 91.7, respectively (p=0.569). When factors affecting OS were examined, visceral recurrence was significantly associated with shorter survival (HR: 0.06, 95% CI: 0.014-0.3, p< 0 .001). With regards to DFS, N2-3 status (HR: 2.33, 95% CI: 1.2-6.69, p= 0.017) and stage 3-4a disease (HR: 3.37, 95% CI: 1.01.-11.1, p= 0.047) were associated with earlier recurrence. 5-year OS and DFS outcomes of our patients with nasopharyngeal carcinoma were consistent with the published data. Our results showed that N2-3 disease was a poor prognostic indicator for DFS; on the other hand, visceral metastasis and recurrence were poor prognostic indicators for OS.