Candida auris Fungemia Confirmed by Sanger Sequencing Method: A Rare Case Report Sanger Sekanslama Metoduyla Doğrulanmış Candida auris Fungemisi: Nadir Bir Olgu Sunumu
Genel Tip Dergisi, cilt.35, sa.4, ss.782-787, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.54005/geneltip.1574493
- Dergi Adı: Genel Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.782-787
- Anahtar Kelimeler: Candida auri, fungemia, resistant
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Candida auris is an important fungal pathogen that has been on the rise worldwide in recent years and has become a serious problem in intensive care units. In our patient with a long history of intensive care unit hospitalization, diabetes mellitus (DM) as a comorbidity, and a history of broad-spectrum antibiotic use, Candida auris (C.auris) was isolated from blood cultures by both MALDI-TOF MS and the Sanger sequencing method. Antifungal susceptibility was determined by the liquid microdilution method, and intravenous caspofungin treatment was first given to the patient. Intravenous liposomal amphotericin B treatment was initiated when C.auris grew again in the blood cultures. Although C.auris eradication was achieved on the 77th day of antifungal treatment and 27th day of amphotericin B treatment, the patient died with septic shock due to panresistant Providencia stuartii infection. Our case is the first reported case from Konya, and clinicians should be cautious against C.auris cases with multidrug resistance, which may lead to outbreaks in intensive care units.