Comparing beneficial effects of inhaled nitric oxide to l-arginine in necrotizing enterocolitis model in neonatal rats
Pediatric Surgery International, cilt.28, sa.12, ss.1219-1224, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 12
- Basım Tarihi: 2012
- Doi Numarası: 10.1007/s00383-012-3181-8
- Dergi Adı: Pediatric Surgery International
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1219-1224
- Anahtar Kelimeler: Necrotizing enterocolitis, L-Arginine, NO
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Necrotizing enterocolitis (NEC) is a common and devastating gastrointestinal condition of neonatal infants. The pathophysiology of NEC remains poorly understood. We tried to evaluate the effectiveness of inhaled NO compared to l-arginine usage in necrotizing enterocolitis model in rats. Material-methods: 46 newborn pups from 4 time-mated Sprague-Dawley pregnant rats were divided equally into 4 groups as follows: NEC (subjected to NEC), NEC + l-arginine, NEC + inhaled NO and control. Results: SOD, GSH-Px and NOx levels were significantly higher and MDA levels were significantly lower in NEC + inhaled NO group compared to NEC + l-arginine group. There was significantly lower intestinal injury and apoptosis index scoring in NEC + inhaled NO group compared to NEC + l-arginine group. Conclusion: We think that inhaled NO can be used as a novel therapeutic agent like l-arginine in NEC, like using in pulmonary hypertention in newborns but much more studies are needed. © 2012 Springer-Verlag Berlin Heidelberg.