Risk factors for lymph node involvement in early-stage cervical cancer: A retrospective cohort study
Journal of Experimental and Clinical Medicine (Turkey), cilt.42, sa.1, ss.1-4, 2025 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.52142/omujecm.42.1.1
- Dergi Adı: Journal of Experimental and Clinical Medicine (Turkey)
- Derginin Tarandığı İndeksler: Scopus, EMBASE
- Sayfa Sayıları: ss.1-4
- Anahtar Kelimeler: cervical cancer, lymph node metastasis, lymph-vascular space invasion, risk factors
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
One of the most important prognostic factors in cervical cancer is lymph node involvement that affects disease-free survival and plays an important role in the treatment. This study aimed to determine the factors affecting lymph node involvement in early stage cervical cancer. A total of 169 cervical cancer patients with stage IA2-IIA2 were enrolled. Age, histologic subtype, deep stromal invasion (DSI), largest tumor diameter (LTD), lymphovascular space invasion (LVSI), vaginal surgical margin, ovarian metastasis status, parametrial involvement, lymph node count and presence of metastasis were retrospectively reviewed. All of these parameters are divided into two groups: LNM positive (group 1) and negative (group 2). The median age of the patients was 52 (26-77) years. In the univariate regression analysis; LVSI (p <0.001), DSI (p=0.018), parametrial involvement (p = 0.001), and vaginal surgical margin positivity (p = 0.020) were in statistically significant correlations with lymph node involvement. In multivariate regression analysis, LVSI [51/118 (43.2%) vs 7/51 (13.7%), OR = 3.9, p = 0.003] and parametrial involvement [(16/24 (66.6%) vs 42/145 (28.9%), OR = 3.9, p = 0.009] were the independent risk factors for lymph node metastasis. LVSI and parametrial involvement are two crucial risk factors for lymph node metastasis in patients diagnosed with early-stage cervical cancer.