Correlation of Urine Haptoglobin and Albumin Levels in Predicting Early Nephropathy in Individuals with Obesity Obezitesi Olan Bireylerde Erken Nefropatiyi Öngörmede İdrar Haptoglobin ve Albümin Düzeylerinin Korelasyonu
Medical Journal of Bakirkoy, cilt.22, sa.3, ss.223-228, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/bmj.galenos.2025.2024.8-9
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.223-228
- Anahtar Kelimeler: Haptoglobinuria, albuminuria, renal function, obesity, type 2 diabetes
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Urine haptoglobin, an alpha-2 sialoglycoprotein, is associated with renal failure even in the early stages. We aimed to determine the correlation between the urinary haptoglobin-to-creatinine ratio (HCR) and the albumin-to-creatinine ratio (ACR) in diabetic, prediabetic, and non-diabetic obese patients without chronic renal failure. Methods: A total of 102 obese individuals aged ≥18 years, including diabetic patients, normoglycemic patients, and patients with impaired fasting glucose disorders, were included in this cross-sectional study. Biochemical and urine parameters, including fasting blood glucose, glycated hemoglobin, renal and liver function tests, and spot urine ACR and HCR, were analyzed. Results: Among study participants, 17.6% (n=18) had impaired fasting glucose, 46.1% (n=47) had type 2 diabetes mellitus, and 36.3% (n=37) were normoglycemic. Urinary ACR was significantly higher and urinary HCR was significantly lower in the diabetic group compared with the other two groups. A moderate, significant positive correlation was observed between ACR and HCR in the diabetic group (r=0.454; p=0.001). Although HCR was significantly higher in non-diabetic individuals with obesity (p=0.011) compared with other groups, no significant relationship was found between ACR and HCR. Conclusion: We determined a relationship between HCR and ACR levels in diabetic patients with obesity. As a result, evaluation of urinary haptoglobin may be useful for predicting nephropathy related to diabetes mellitus and obesity. Further large-sample prospective studies are warranted to reach more precise conclusions regarding variations in HCR in the obese population.