Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis
Fertility and Sterility, cilt.90, sa.4, ss.988-993, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 90 Sayı: 4
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.fertnstert.2007.07.1332
- Dergi Adı: Fertility and Sterility
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.988-993
- Anahtar Kelimeler: ovarian endometriosis, angiogenesis, cyclooxygenase-2, vascular endothelial growth factor, microvessel density, immunohistochemistry
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To investigate the expression of cyclooxygenase-2 (Cox-2) and vascular endothelial growth factor (VEGF) in ovarian endometriotic cysts and assess their relation with angiogenesis. Design: Experimental clinical study. Setting: University hospital. Patient(s): Fifty patients with ovarian endometriotic cysts. Intervention(s): Surgical excision of 50 ovarian endometriotic cysts. Main Outcome Measure(s): Microvessel density and the expression of Cox-2 and VEGF were analyzed immunohistochemically. Result(s): Cyclooxygenase-2 immunoreactivity was mainly cytoplasmic in glandular epithelial cells in all of the ovarian endometriotic cysts, with low expression in 12 cases (24%), moderate expression in 21 (42%), and high expression in 17 (34%). Vascular endothelial growth factor immunoreactivity was mainly cytoplasmic in stromal cells in 46 (92%) of the ovarian endometriotic cysts, with low expression in 12 cases (24%), moderate expression in 18 (36%), and high expression in 16 (32%). No immunoreactivity was present in 4 cases (8%). Both Cox-2 (r = 0.728) and VEGF (r = 0.670) were closely, statistically significantly related with microvessel density in ovarian endometriotic cysts. Cyclooxygenase-2 and VEGF also were highly statistically significantly correlated (r = 0.777) with each other. Conclusion(s): We observed Cox-2 expression mostly in glandular epithelial cells of ovarian endometriotic cysts, whereas VEGF expression was observed mainly in stromal cells. Cyclooxygenase-2 and VEGF were closely correlated with each other, and both of them appear to play a role in the angiogenesis of ovarian endometriosis. © 2008 American Society for Reproductive Medicine.