Retrospective Evaluation of Coaxial Core Needle Biopsy Results Performed on Mammographic Suspicious Microcalcifications of the Breast Memenin Kuşkulu Mikrokalsifikasyonlarına Mamografide Yapılan Koaksiyel Kalın İğne Biyopsi Sonuçlarının Retrospektif Değerlendirilmesi
Anatolian Journal of General Medical Research, cilt.36, sa.1, ss.45-52, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/anatoljmed.2025.52824
- Dergi Adı: Anatolian Journal of General Medical Research
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.45-52
- Anahtar Kelimeler: breast cancer, core needle biopsy, Mammography, microcalcification
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Breast microcalcifications (MCs) are detected in approximately one-third of screening mammograms and are associated with about 40% of breast cancers. The gold-standard procedure for histopathological evaluation of MCs is stereotactic vacuum-assisted biopsy; however, it is costly and not easily accessible. The aim of this study was to evaluate the feasibility of stereotactic coaxial core needle biopsy (CNB), a less expensive and simpler technique, for MCs detected on mammography and to investigate its specificity, positive predictive value (PPV), negative predictive value (NPV), and sensitivity. Methods: Between 2020 and 2024, 76 who underwent stereotactic coaxial CNB for breast imaging reporting and data system (BI-RADS) category 4-5 MCs detected on mammography were retrospectively reviewed. Results: The specificity and PPV of the biopsy procedure were 100%, while the sensitivity and NPV were 71.4% and 85.7%, respectively. A calcification size of ≤10 mm (p=0.077) and obtaining ≥10 samples (p=0.034) were found to be significant factors for biopsy accuracy. Segmental distribution, fine pleomorphic and fine linear morphologies, and BI-RADS categories 4C and 5 were significantly associated with malignancy (p<0.001). Conclusion: For MCs detected on mammography that are suspected to be malignant but not localized by ultrasonography, coaxial CNB performed under mammographic guidance provides high diagnostic accuracy and reliability.