Analysis of lymphocyte subgroups in Crimean-Congo hemorrhagic fever

AKINCI E., Yilmaz M., BODUR H., ÖNGÜRÜ P., Bayazit F. N., ERBAY A., ...Daha Fazla

International Journal of Infectious Diseases, cilt.13, sa.5, ss.560-563, 2009 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ijid.2008.08.027
  • Dergi Adı: International Journal of Infectious Diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.560-563
  • Anahtar Kelimeler: Crimean-Congo hemorrhagic fever, Lymphocyte subgroups, T Lymphocytes
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objectives: This study examined the association between lymphocyte subgroups and mortality in patients with Crimean-Congo hemorrhagic fever (CCHF) in Turkey. Methods: During the spring and summer of 2007, peripheral blood was collected from hospitalized patients with suspected CCHF. Lymphocyte subgroups were characterized by fluorescence-activated cell sorting. CCHF cases were confirmed by detecting viral RNA by PCR and/or IgM antibodies by ELISA. Lymphocyte subgroups were compared between fatal and non-fatal cases. The correlation between lymphocyte subgroups and viral loads was also investigated. Results: Seventy-seven confirmed cases of CCHF were included in this study (five cases were fatal (6.5 %)). No differences in lymphocyte subgroups were found between fatal and non-fatal cases, except for significantly higher CD3+CD8+ T cells in the fatal cases (p = 0.017). A positive correlation between viral load and CD3+CD8+ T cells was also detected (p = 0.044). There was no correlation between other lymphocyte subgroups and viral load. Conclusions: Higher levels of CD3+CD8+ T lymphocytes were detected in fatal compared to non-fatal CCHF cases. Despite this cytotoxic immune activation, a fatal outcome could not be prevented. We hypothesize that high viral load and other factors may influence this outcome, although more studies are required to explain the pathogenesis of CCHF. © 2008 International Society for Infectious Diseases.