Recurrent Brain Metastasis of Triple Negative Breast Cancer with High Uptake in 68Ga-PSMA-11 PET/CT
Clinical Nuclear Medicine, cilt.46, sa.2, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.1097/rlu.0000000000003336
- Dergi Adı: Clinical Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: triple negative breast cancer (TNBC), F-18-FDG, Ga-68-PSMA-11, PET/CT
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Triple negative breast cancer (TNBC) is characterized by poor prognosis and limited response to standard treatments. Although 18F-FDG PET/CT is frequently used in staging and restaging, in some cases, it may be insufficient considering tumor heterogeneity. Prostate-specific membrane antigen (PSMA) has been reported to be overexpressed in many types of cancer due to tumor-associated neovascularization. 68Ga-PSMA-11 PET/CT can be used to demonstrate radionuclide therapy option as well as detection of primary tumor and recurrence in TNBC. We present a 47-year-old woman with TNBC having recurrent brain metastasis with avid PSMA receptor activity versus low FDG uptake.