Effects of hypothermia and cardiopulmonary bypass on cold agglutinins Kardiyopulmoner Baypas ve Hipoterminin Soǧuk Aglutinin Üzerine Etkileri
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, cilt.9, sa.4, ss.167-171, 2003 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 4
- Basım Tarihi: 2003
- Dergi Adı: Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.167-171
- Anahtar Kelimeler: Cardiopulmonary bypass, Cold agglutinin, Hypothermia, Plasma proteins
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
The Effects of Hypothermia on cold agglutinins in patients undergoing cardiopulmonary bypass (CPB) surgery for myocardial revascularization was studied prospectively in 33 patients (median; range 36 to 76 years). After premedication and induction of anaesthesia CPB was initiated and patients were cooled to 28°C. During CPB, 23 patients were given "Edward" cardioplegia (crystalloid cardioplegia) (Group I) and 10 patients blood cardioplegia (Group II)for myocardial protection. At the following periods, 3 mL blood samples were drawn and tested for cold agglutination; preoperative period, during CPB just before rewarming (I. blood sample), postoperative at the 2. hour (II. blood sample) and 24. hour (III. blood sample). Demografic data, durations of aortic cross-clamp, CPB and operation were similar in the two groups. All the patients were cold agglutinin (-) preoperatively. Only 4 patients were cold agglutinin (+) at different times with different titers (1/4-1/32) afterwards. Type of cardioplegia did not influence peroperative agglutination tests. There were no statistically significant differences between group I and II and periods within the groups with respect to cold agglutination. While the patients in the study group were cold agglutinin (-) preoperatively we found an incidence of 1.2% cold agglutination at 1/4-1/64 titers in 1000 patients who were tested for cold agglutination for various reasons in our hospital. In conclusion; independent of the type of cardioplegia; although, none of our patients undergoing moderate hypothermia had clinically important cold agglutination, agglutinin titers with thermal amplitude should be determined whenever deep hypothermia is needed.