Correlation of biochemical markers with histopathological findings in experimental strangulated hernia Deneysel boǧulmuş fıtık modelinde biyokimyasal ve histopatolojik bulguların karşılaştırılması
Trakya Universitesi Tip Fakultesi Dergisi, cilt.27, sa.3, ss.287-291, 2010 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 3
- Basım Tarihi: 2010
- Doi Numarası: 10.5174/tutfd.2009.01398.2
- Dergi Adı: Trakya Universitesi Tip Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.287-291
- Anahtar Kelimeler: Strangulated hernia, D-dimer, ALT, AST, CPK
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: This study was planned to evaluate whether possible changes in the hematological parameters and the biochemical markers can be used to detect obstruction-induced (strangulated) intestinal ischemia. Materials and Methods: Forty rats divided into five groups underwent the following procedures: Group 1 rats were treated with only laparotomy (sham-operated controls). To the strangulated hernia groups surgical induction of strangulated intestinal obstruction was performed. Tissue and blood samples were taken at 30 minutes (group 2), 2nd hour (group 3), 4th hour (group 4) and 6th hour (group 5) respectively, and then LDH, CPK, ALP, AST, ALT, D-dimer levels and blood cells counts were measured and histopathological examination was done. Results: Focal mucosal necrosis accompanied was confirmed by histological findings in the strangulated intestinal ischemia group after second hour. Serum D-dimer, ALT, ALP, CPK levels and neutrophil count became elevated at second hour, which was statistically significant. Conclusion: In patients with hernia, after reduction of the intestinal hernia, raised levels of serum D-dimer, ALT, ALP, CPK levels and neutrophil count may indicate the presence of a bowel ischemia. However, more comprehensive clinical studies are required to evaluate the potential survival benefit by using the laboratory tests as a marker and/or a useful diagnostic tool of the need for laparotomy. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.