Transient efficacy of double high-dose chemotherapy and autologous peripheral stem cell transplantation, immunoglobulin, thalidomide, and bortezomib in the treatment of scleromyxedema
American Journal of Clinical Dermatology, cilt.9, sa.4, ss.271-273, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 4
- Basım Tarihi: 2008
- Doi Numarası: 10.2165/00128071-200809040-00008
- Dergi Adı: American Journal of Clinical Dermatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.271-273
- Anahtar Kelimeler: Bortezomib, therapeutic use, Melphalan, therapeutic use, Myxoedema, Stem cell transplant, Thalidomide, therapeutic use
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Scleromyxedema is a rare disorder characterized by mucin deposits in the dermis and monoclonal gammopathy. No definitive treatment of this condition has been described to date. We present the case of a 38-year-old male patient with scleromyxedema who underwent double consecutive autologous peripheral stem cell transplantations and received immunoglobulin, thalidomide, and bortezomib. This resulted in considerable clinical and pathologic amelioration of the patient's condition. However, 3 years after the second transplant, the patient relapsed and manifested the same skin lesions evident at his initial presentation. © 2008 Adis Data Information BV. All rights reserved.