The prognostic value of mean platelet volume levels in germinal matrix hemorrhage-intraventricular hemorrhage in preterm infants
Pakistan Journal of Medical Sciences, cilt.41, sa.4, ss.1145-1150, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.12669/pjms.41.4.11642
- Dergi Adı: Pakistan Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.1145-1150
- Anahtar Kelimeler: Germinal matrix, Intraventricular hemorrhage, Mean platelet volume, Neonate, Preterm
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH) is currently the most significant cause of brain damage and mortality seen in preterm infants. The aim of this study was to evaluate the predictive value of mean platelet volume (MPV) in diagnosing GMH-IVH and mortality. Method: A retrospective-cohort study of preterm infants with a gestational age <32 weeks or with birthweight <1500gr who were admitted to the Neonatal Intensive Care Unit was conducted between January 2020 and January 2022. These infants were then classified into two groups according to the presence of GMH-IVH. Results: Overall, 136 preterm infants were enrolled. The MPV levels were significantly higher in the GMH-IVH group (p <0.001). A MPV cutoff of >9.95 was determined to be predictive for GMH-IVH with sensitivity of 62% and specificity of 80% (p < 0.001). Mortality was significantly higher in the GMH-IVH group (p<0.001). A MPV cutoff of >10.55 fL was determined to predict mortality with 77% sensitivity and 70% specificity (p < 0.001). Conclusions: The MPV value is significantly higher in infants with GMH-IVH and therefore can be used in the prediction of GMH-IVH and mortality in preterm infants.