The TAP Block Reduces Oxidative Stress and Postoperative Pain in Laparoscopic Gynecological Surgery TAP Bloğu Laparoskopik Jinekolojik Cerrahide Oksidatif Stresi ve Postoperatif Ağrıyı Azaltır
Medical Journal of Bakirkoy, cilt.22, sa.1, ss.72-78, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/bmj.galenos.2025.2025.4-3
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.72-78
- Anahtar Kelimeler: Laparoscopic gynecological surgery, oxidative stress, pain, regional anesthesia, thiol-disulphide homeostasis, transversus abdominis plane block
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Postoperative pain is a significant concern in laparoscopic gynecological surgery, and its management typically includes regional analgesia techniques, such as the transversus abdominis plane (TAP) block, alongside systemic analgesics. Thiol-disulphide homeostasis (TDH) measurements are used to assess oxidative stress. This study investigated the effect of TAP block on TDH and postoperative pain. Methods: The study included patients who underwent laparoscopic total abdominal hysterectomy and bilateral salpingo-oophorectomy. While a TAP block was performed following anesthesia induction in Group T, local anesthetic infiltration was administered at the trocar insertion sites prior to trocar placement in Group I. Blood samples were taken at anesthesia induction and at the 24th postoperative hour. Results: In Group T, we observed higher levels of native thiol (NT), total thiol (TT), and the NT/TT ratio, whereas disulphide/NT and disulphide/ TT ratios, and ischemia-modified albumin values were lower than in Group I. Additionally, postoperative pain scores were lower in Group T at 0, 2, and 4 hours. Conclusion: In this study, we found that TAP block combined with general anesthesia reduced oxidative stress and postoperative pain. We conclude that the combination of general anesthesia and regional analgesia has beneficial effects on both oxidative stress and pain management.