Factors Associated With 30-Day Mortality in Intensive Care Unit Patients with Coagulase-Negative Staphylococcal Bloodstream Infections Yoğun Bakım Ünitesinde Koagülaz-negatif Stafilokokların Etken Olduğu Kan Dolaşımı İnfeksiyonlarında 30 Günlük Mortalite ile İlişkili Faktörler

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Çaydaşı Ö., Arslan E., Olçar Y., Elbasan-Omar Ş., Şabablı-Çetin A., Türkmen M., ...Daha Fazla

Klimik Dergisi, cilt.39, sa.2, ss.106-112, 2026 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2026
  • Doi Numarası: 10.36519/kd.2026.5417
  • Dergi Adı: Klimik Dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, CINAHL, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
  • Sayfa Sayıları: ss.106-112
  • Anahtar Kelimeler: Bloodstream infection, coagulase-negative staphylococci, mortality, procalcitonin
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: Coagulase-negative staphylococci (CoNS) are leading causes of healthcare-associated bloodstream infections (BSIs) and pose a significant clinical challenge in intensive care units (ICUs). This study aimed to identify clinical and laboratory parameters associated with 30-day mortality in ICU patients with CoNS-related BSI. Methods: This retrospective study included patients aged 18 years or older who were hospitalized in the ICU between January 1 and November 1, 2024, and had the same CoNS species isolated from two separate blood culture sets. De-mographic characteristics, clinical findings, laboratory results, and microbiological data were evaluated. Factors associated with 30-day mortality were investigated using receiver operating characteristic (ROC) curve analysis and multivariate logistic regression analysis. Results: A total of 173 patients were included in the study. The median age was 75 years (interquartile range [IQR], 66–81), and 42.8% were female. Staphylococcus epidermidis was the most frequently isolated species (42.2%), and 95.3% of isolates were methicillin-resistant. Septic shock was present in 45% of patients. The 30-day mortality rate was 71.6%. Compared with survivors, nonsurvivors had significantly higher procalcitonin (PCT) levels (1.46 vs 0.58 ng/ mL; p=0.002) and lactate levels (2.25 vs 1.97 mmol/L; p=0.044), whereas platelet counts were significantly lower (182 500 vs 282 000/mm³; p<0.001). In multivariate analysis, platelet count ≤194 000/mm³ [odds ratio (OR): 5.94; 95% con-fidence interval (CI): 2.53–13.97; p<0.001] and PCT level >0.67 ng/mL (OR: 3.14; 95% CI: 1.50–6.57; p=0.002) were independently associated with 30-day mortality. Conclusion: In patients with CoNS-related BSI, elevated PCT levels and low platelet counts were independently associated with 30-day mortality. These findings may contribute to early prognostic assessment and risk stratification in critically ill patients.