The impact of myasthenia gravis on lower urinary tract functions
International Journal of Clinical Practice, cilt.75, sa.12, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 75 Sayı: 12
- Basım Tarihi: 2021
- Doi Numarası: 10.1111/ijcp.14873
- Dergi Adı: International Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To assess the functions of the lower urinary tract (LUT) in patients with myasthenia gravis (MG). Materials and Methods: A total of 36 patients (18 males and 18 females) with MG and 29 healthy controls were enrolled. Participants completed a 3-day voiding diary and responded to questionnaires "Overactive Bladder Symptom Score" (OABSS) and "International Consultation on Incontinence-Short Form" (ICIQ-SF). All patients underwent uroflowmetry and ultrasonography (US). The data were compared based on the onset of disease and serological status. Results: The most common urinary symptoms were nocturia (80.5%), incontinence (61%) and urgency (47%). OABSS was higher in patients than controls (P =.008). Duration of urinary symptoms was longer, and nocturia was more common in late-onset MG (LOMG) than in early-onset MG (EOMG; P =.029, P =.023). The duration of disease and urinary symptoms statistically increased in ACh-Ab (−) group compared with ACh-Ab (+) group (P =.003, P =.027). Night-time urination frequency significantly increased while daytime voided volume (VV) decreased in LOMG compared with EOMG (P =.003 and P =.01). Residual volume on the US was significantly higher in LOMG than that in EOMG (P =.004). The duration of disease was positively correlated with tQmax and daytime urination frequency (P =.013, r =.48; P =.016, r =.398). A negative association was found between duration of disease and daytime VV (P =.04, r = −.344). Conclusion: LUT dysfunction may manifest disease in MG, particularly in late-onset forms. The lack of ACh-Ab seemed to prolong the duration of disease and urinary disturbances.