Could computed tomography hounsfield unit values of lumbar verte-brae detect osteoporosis?
Current Medical Imaging, cilt.17, sa.8, ss.988-995, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 8
- Basım Tarihi: 2021
- Doi Numarası: 10.2174/1573405617999210112193545
- Dergi Adı: Current Medical Imaging
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
- Sayfa Sayıları: ss.988-995
- Anahtar Kelimeler: Osteoporosis, hounsfield unite (HU), T-score, computed tomography, lumbar spinal degeneration, bone mineral density
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Dual-energy X-ray absorptiometry (DEXA) scanning has several disad-vantages determining osteoporosis, especially for the degenerative spine. Introduction: This study aims to determine spinal osteoporosis in patients suffering from lumbar degenerative disease using computed tomography (CT). Methods: A total of 547 subjects that underwent DEXA and abdominal CT within a period of three months were examined retrospectively and separated into groups based on lumbar degenerative al-teration on the CT scan. The subjects that showed degenerative severity at L1–L4, in at least two levels, were graded and placed in the degenerative group (Group D, n=350). In contrast, the other subjects constituted the control group (Group C, n=197). The Hounsfield unit (HU) of the vertebral body trabecular bone, the T-score, and bone mineral density (BMD) of L1–L4 and hips were determined from the CT images. CT-HU parameters for osteoporosis acquired from the control group were used to ascertain undiagnosed osteoporosis. Results: The CT-HU was positively correlated with T-score and lumbar BMD for both groups (P<0.001), while the L1–L4 correlation was higher in Group C than in Group D. Based on linear regression, the T-score and CT-HU for L1-L4 osteoporosis were 129, 136, 129 and 120 HU, respectively in Group C. Undiagnosed spinal osteoporosis was greater in Group D compared to the con-trols (44.2% vs. 9.6%, respectively) based on the CT-HU thresholds. Conclusion: Lumbar spine degeneration can augment BMD and T-score, resulting in the underesti-mation of lumbar osteoporosis. The osteoporosis threshold determined by CT-HU may be a valu-able technique to determine undiagnosed spinal osteoporosis.