Metabolomic profiles of body fluids in preterm births
Metabolomics and Clinical Approach, NOVA Publications , ss.271-286, 2023
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2023
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.271-286
- Anahtar Kelimeler: Body fluids, Metabolomics, Newborn, Perinatal medicine, Precision medicine, Preterm birth
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Preterm birth is a multi-sided condition affecting more than 15 billion infants and women per year around the world. In the challenges of dealing with preterm birth and its accompanying morbidities, including respiratory and neurological disorders, increase the medical and pecuniary burden due to the increased survival of very preterm infants. Therefore, prevention and early detection of preterm birth associated mortality and/or morbidity is crucial to deal with these challenges. Metabolomics are promising 'clue' molecules of human metabolism. Maternal, fetal, and neonatal body fluids include many metabolomics that can be used as either early biomarkers or targeted therapeutic molecules of major preterm birth-related morbidities, including respiratory distress syndrome, pulmonary hypertension, and bronchopulmonary dysplasia. Given the wide range of prematurity associated disorders and human body fluid bioenvironment, more metabolomics are expected to be identified to improve quality of care. Thus, future research on body fluid metabolomics is expected to bring today's individualized medicine closer to predict PTB by providing a better understanding of its underlying mechanisms.