Placental growth factor: As an early second trimester predictive marker for preeclampsia in normal and high-risk pregnancies in a turkish population
Journal of Obstetrics and Gynecology of India, cilt.63, sa.3, ss.158-163, 2013 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 3
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/s13224-012-0279-9
- Dergi Adı: Journal of Obstetrics and Gynecology of India
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.158-163
- Anahtar Kelimeler: Preeclampsia, Angiogenesis, Placental growth factor
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Placental growth factor (PlGF) is an angiogenetic factor and inducts the development of preeclampsia in a hypoxic environment. In this study, we examined maternal blood PlGF levels in a pregnant population between 16 and 19 weeks of gestation for determining the prospective value for early diagnosis of preeclampsia as a screening test. Materials and Methods: In this prospective cross-sectional study, 114 nulliparous normotensive pregnant women were selected for the control group and 34 patients who have chronic hypertension or had a medical history of hypertensive disorders in previous pregnancies were selected for the study group. Results: In the study group, the risk of preeclampsia increased 3.2 times when compared with the control with a confidence interval of 95 %. The cut-off value for PlGF for discriminating preeclamptic and non-preeclamptic patients was found to be 62.5 pg/ml. Conclusion: Patients with a medical history of hypertensive disorders and low PIGF levels in early second trimester have an increased risk for preeclampsia. © 2012 Federation of Obstetric & Gynecological Societies of India.