PHYTOCHEMICAL PROFILING AND ANTIOXIDANT PROPERTIES OF AJANIA FASTIGIATA (C. WINKL.) POLJAKOV (ASTERACEAE)
Farmacia, cilt.73, sa.4, ss.1038-1046, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.31925/farmacia.2025.4.23
- Dergi Adı: Farmacia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.1038-1046
- Anahtar Kelimeler: Ajania fastigiata, phytochemical profiling, antioxidant activity, GC-MS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
This study aims to evaluate the phytochemical composition and antioxidant properties of Ajania fastigiata (C. Winkl.) Poljakov, a medicinal plant native to Kazakhstan. For the first time, a comprehensive GC-MS-based phytochemical profiling of this species was conducted, revealing a unique chemical composition. GC-MS analysis identified 26 bioactive compounds in the ethanol extract, with bicyclo[3,1,1]hept-3-en-2-ol, 4,6,6-trimethyl-(30.6%), hexadecanoic acid (11.0%) and 9,12,15-octadecatrienoic acid (10.7%) as the major constituents. The ethanol extract showed the highest total phenolic content (65.7 mg GAE/g) and flavonoid content (7.18 mg QE/g). Antioxidant activity, evaluated through DPPH and FRAP assays, demonstrated significant radical scavenging capacity (79.21% at 1 mg/mL) and reducing power (1.3727 OD at 1 mg/mL), comparable to gallic acid. The essential oil contained camphor, α-pinene and carvacrol. These findings highlight Ajania fastigiata as a promising natural source of antioxidants and support its potential for pharmaceutical and therapeutic applications. Rezumat.