Comparison of different calculation indexes with dose volume histogram parameters for evaluation of radiation treatment plans in gynecologic malignancies
International Journal of Radiation Research, cilt.18, sa.3, ss.477-486, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.18869/acadpub.ijrr.18.3.477
- Dergi Adı: International Journal of Radiation Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.477-486
- Anahtar Kelimeler: Gynecological radiotherapy, treatment planning, dosimetric evaluation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: We aimed to investgate the accordance of Critcal Organ Scoring Index (COSI), Conformity Index (CI) and Normal Tissue Complicaton Probability (NTCP) parameters with Dose Volume Histograms (DVH) used for evaluaton of 3 different pelvic radiotherapy plans. Materials and Methods: Ten gynecologic carcinoma patents who underwent adjuvant radiotherapy were enrolled in this study. Treatment plans were created with conformal treatment planning (3DCRT) and intensity modulated radiaton therapy (IMRT) to a total dose of 50.4 Gy in 28 fractons. Initally, volume related dose evaluaton was done via DVH. Subsequently, HI, CI, COSI and NTCP for selected normal tssues were calculated for each plan and compared with DVH parameters. Finally, a graphical demonstraton was evaluated to see if the results were in accordance with DVH. Results: CI results were statstcally significant in favor of IMRT (p<0.001). Rectum V40Gydecreased with 9IMRT compared to 3DCRT and 7IMRT (p=0.013 and p=0.013). V40Gyfor bladder was also lower with 9IMRT compared with 3DCRT and 7IMRT (p=0.005 and p=0.012). COSI calculatons revealed beter small intestne protecton in IMRT plans similar with DVH (p=0.005 and p=0.022). Femoral heads were beter protected with IMRT plans were beter compared to 3DCRT in NTCP calculatons (p=0.002). Normal tssue protecton was worst with 3DCRT via both DVH and COSI evaluatons (p=0.001 and p<0.001 respectvely). Conclusion: Using the indexes in this study to decide the most appropriate plan among multple treatment plans in gynecologic cancer patents will be tmesaving and easier in comparison with evaluatng the DVH of every alternatve plan.