The effects of topical latanoprost 0.005% treatment on microvascular changes in the optic nerve head and macula
Indian Journal of Ophthalmology, cilt.72, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72
- Basım Tarihi: 2024
- Doi Numarası: 10.4103/ijo.ijo_648_24
- Dergi Adı: Indian Journal of Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Latanoprost, optic nerve head, optical coherence tomography angiography, primary open-angle glaucoma, retinal microvasculature, vascular density
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: This prospective study aimed to assess the impact of topical latanoprost 0.005% treatment on the microvasculature of the macula and optic nerve head (ONH) in primary open-angle glaucoma (POAG). Methods: Fifty-seven eyes of 31 subjects were enrolled. ONH whole-image (wiVD), peripapillary (ppVD), and macular vascular density (VD) parameters were measured using optical coherence tomography angiography before treatment, at the 1 st month, and at the 3 rd month of treatment. Results: There was a significant reduction in IOP post treatment, with a decrease of 17.0 ± 2.3 mmHg in the 1 st month and 16.3 ± 2.5 mmHg in the 3 rd month (P < 0.001 for both). ONH wiVD and ppVD significantly increased at the post-treatment 1 st month (P = 0.001 for both) but decreased by the 3 rd month, returning to baseline levels (P < 0.001 for both), indicating a return to pre-treatment levels (P > 0.05 for both). Similarly, macular wiVD and perifoveolar VD (pefVD) increased significantly at the 1 st month (P = 0.013 and P < 0.001, respectively) but returned to baseline by the 3 rd month (P < 0.001 for both). No significant difference was observed between before-treatment and post-treatment 3 rd month regarding the macular wiVD and pefVD (P > 0.05 for both). Deep capillary plexus and foveal avascular zone parameters did not change during follow-up (P > 0.05 for both). Conclusion: The initial increase in ONH and peripapillary VD, as well as macular VD, is attributed to the acute reduction in IOP from topical latanoprost 0.005%. However, the diminishment of sustained differences by the 3 rd month indicates adaptation of the ONH and retinal microvasculature to decreased IOP through compensatory mechanisms.