Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia
Hypertension in Pregnancy, cilt.40, sa.3, ss.186-192, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/10641955.2021.1921793
- Dergi Adı: Hypertension in Pregnancy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.186-192
- Anahtar Kelimeler: Preeclampsia, CRP, interleukin-1β, uric acid, MPV, vitamin D, calcium, magnesium
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.