Effect of octreotide in the prevention of doxorubicin cardiotoxicity
Anadolu Kardiyoloji Dergisi, cilt.5, sa.1, ss.18-23, 2005 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 1
- Basım Tarihi: 2005
- Dergi Adı: Anadolu Kardiyoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.18-23
- Anahtar Kelimeler: Cardiotoxicity, Doxorubicin, Octreotide, Prevention
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: A precise method for prevention from doxorubicin cardiotoxicity is not known. We examined whether octreotide has a protective effect against doxorubicin cardiotoxicity. Methods: New Zealand rabbits (n=44) were divided into 4 groups according to drugs given: Group A (n=12) doxorubicin and octreotide, Group B (n=12) only doxorubicin, Group C (n=10) only octreotide and Group D (n=10) only saline. Effects of the drugs were evaluated in terms of histopathological score, fractional shortening (FS) and prolongation of the QTc interval. Results: Mean pathological score for cardiotoxicity (Group A: 3.7±0.5, Group B: 3.9±0.3), prolongation of QTc (Group A: from 244.5±21.2ms to 282.9±25.9ms, p<0.0001; Group B: from 248.5±17.7ms to 298.3±13.7ms, p<0.00001) and the rate of decrease in FS (Group A: from 34.4±2.0 to 28.0 ± 2.0, p<0.05; Group B: from 35.1 ± 1.9 to 24.8 ± 1.3, p<0.05) were higher in Group B when compared to Group A, but only difference in the rate of decrease in FS was statistically significant (p<0.001). None of these variables changed significantly in groups C and D. Conclusion: In this preliminary study, octreotide seems not to reduce doxorubicin cardiotoxicity. On the other hand, a consistent tendency of decreased cardiotoxicity in octreotide+doxorubicin group was observed, although only the difference in FS decrease was significant. Futher investigations are needed to address the issue of the extent and the mechanisms of this effect.