Pseudothrombocytopenia Case Report Psödotrombositopeni Olgu Sunumu
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.81, sa.2, ss.201-204, 2024 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 81 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.5505/turkhijyen.2024.10692
- Dergi Adı: Turk Hijyen ve Deneysel Biyoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.201-204
- Anahtar Kelimeler: complete blood count, EDTA, EDTA, pseudothrombocytopenia, psödotrombositopeni, tam kan sayımı, Thrombocytopenia, Trombositopeni
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Pseudothrombocytopenia is a condition in which platelets are seen in sufficient numbers and aggregated in the peripheral smear although the platelet count is low in the complete blood count analysis of the patient. One of the causes of pseudothrombocytopenia is the Ethylenediamine Tetraacetic acid (EDTA) anticoagulant used for routine complete blood count samples. EDTA has a calcium chelator effect and changes the structure of the GPIIb/IIIa integrin complex found in platelets. The hidden GPIIb epitope is revealed as a result of the change in the structure of the GPIIb/IIIa integrin complex, and antibodies are formed against this epitope. These antibodies cause platelet aggregation. Due to aggregation of platelets, complete blood count analysis may give erroneous results and may be confused with true thrombocytopenia. Pseudothrombocytopenia is not a bleeding diathesis, but patients may be subjected to unnecessary diagnostic procedures and treatments. This case report was prepared to emphasize the clinical picture of EDTA-induced pseudothrombocytopenia. In our case, thrombocytopenia was observed as a result of the analysis of the EDTA whole blood count sample taken from the patient who was admitted to the internal medicine outpatient clinic for routine controls. Complete blood count analysis over the past three years also observed thrombocytopenia. It was deemed görülmüştür. Hastadan, sitratlı tüpe alınan tam kan sayımı numunesinin gönderilmesi uygun görülmüştür. Hastadan alınan sitratlı tam kan sayımı numunesinin analizinde, trombosit sayısının normal olduğu görülmüştür. Eş zamanlı yapılan periferik yayma, psödotrombositopeni şeklinde rapor edilmiştir.