An Update of the Efficacy and Comparative Characteristics of Direct (New) Oral Anticoagulants (DOACs)
Cardiovascular and Hematological Agents in Medicinal Chemistry, cilt.20, sa.2, ss.114-124, 2022 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 20 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.2174/1871525719666210914112402
- Dergi Adı: Cardiovascular and Hematological Agents in Medicinal Chemistry
- Derginin Tarandığı İndeksler: Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.114-124
- Anahtar Kelimeler: Anticoagulation, Direct oral anticoagulants, New oral anticoagulants, Throm-boembolic disease, Thrombosis, Venous thromboembolism
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Direct (New-generation) Oral Anticoagulants (DOACs) have emerged as effective agents which are used in place of vitamin-K antagonists in treatment and prophylaxis of Venous Thromboembolism (VTE), atrial fibrillation and other thrombotic diseases. Among them, the FII-a-direct thrombin inhibitor dabigatran and FXa inhibitors (rivaroxaban, apixaban, edoxaban) are the most broadly used. Anticoagulant dosing may differ under special considerations. The patients’ physiological reserves, organ functional status and failures should be taken into account in clinical decision-making processes. The advantages and drawbacks of each specific agent should be weighed with special regard to metabolism, pharmacokinetics and pharmacodynamics, along with the efficiency of the agents in different indications. This article aims to review the most recent literature to highlight the usage and efficacy of the agents in different clinical conditions.