Prognostic nutritional index predicts mortality in infective endocarditis Prognostik nutrisyonel indeks enfektif endokardit hastalarinda mortaliteyi öngördürür
Turk Kardiyoloji Dernegi Arsivi, cilt.48, sa.4, ss.392-402, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 4
- Basım Tarihi: 2020
- Doi Numarası: 10.5543/tkda.2020.25899
- Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.392-402
- Anahtar Kelimeler: Albumin, infective endocarditis, in-hospital mortality, lymphocyte, prognosis, prognostic nutritional index
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The prognostic nutritional index (PNI), based on serum albumin and lymphocyte concentration, is an inflammation- based nutritional score that has been shown to be a prognostic determinant in several populations. The aim of this study was to investigate the impact of PNI on mortality in patients with infective endocarditis (IE). Methods: A total of 131 patients with IE were enrolled in this retrospective study. The patients were divided into 2 groups based on in-hospital mortality. The PNI value of the patients was evaluated, as well as baseline clinical and demographical variables. Results: Among the study group, 29 patients died in-hospital during the median follow-up of 37 days. The PNI was found to be lower in cases of mortality (35.90±6.96; 31.09±5.88; p=0.001). ROC curve analysis also demonstrated that the PNI had a good predictive value for in-hospital mortality with a cut-off value of 35.6 (Area under the curve: 0.691; 95% confidence interval [CI]: 0.589-0.794; p=0.002). In multivariate logistic regression analysis, advanced age (Odds ratio [OR]: 1.078; 95% CI: 1.017-1.143; p=0.012), PNI (OR: 0.911; 95% CI: 0.835-0.993; p=0.034), and leaflet perforation (OR: 5.557; 95% CI: 1.357-22.765; p=0.017) were found to be independent predictors of mortality. Kaplan- Meier survival analysis revealed that long-term survival was found to be significantly decreased in patients with a lower PNI (Log rank: p=0.008). Conclusion: The PNI result was associated with an increased in-hospital mortality rate in patients with IE. The PNI value, advanced age, and cardiac valve perforation as a complication of IE were found to be independent predictors of mortality.