Procalcitonin and C-reactive protein kinetics in pediatric cardiac surgery Pediyatrik Kalp Cerrahisinde Prokalsitonin ve C-reaktif Protein Kinetiǧi
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, cilt.12, sa.1, ss.19-25, 2006 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 1
- Basım Tarihi: 2006
- Dergi Adı: Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.19-25
- Anahtar Kelimeler: C-reactive protein, Pediatrik cardiac surgery, Procalcitonin
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this prospective study we evaluated the procalcitonin (PCT) and C-reactive protein (CRP) kinetics in pediatric patients with or without sytemic inflammatory response after open heart surgery. Forty pediatric patients undergoing open heart surgery were included into this study. Patients were divided into two groups according to their postoperative course: twenty five patients with systemic inflammatory response syndrome (GROUP I) (n=25) and 15 patients without SIRS (GROUP II). Plasma PCT and CRP levels were measured before and after the operation, and 1, 2, 3, 4 days after surgery, Postoperative PCT levels of GROUP I were significantly higher than GROUP II. CRP values were similar among the groups throughout the study period except for the significantly high values of GROUP I on postoperative days 1, 2 and 3. Median CRP values peaked on postoperative day 2, whereas PCT peaked on postoperative day 1. Peak PCT levels were found to be positively correlated only with CPB (cardiopulmonary bypass) time. However CRP values were not found to be correlated with any clinical variable. Mechanical ventilation, ICU and hospitalization periods were identical among the groups. In conclusion, PCT was found to be a better SIRS monitor compared to CRP after pediatric open heart surgery.