HDL-cholesterol is associated with systemic inflammation in cardiac syndrome X
Minerva Medica, cilt.106, sa.3, ss.133-141, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 106 Sayı: 3
- Basım Tarihi: 2015
- Dergi Adı: Minerva Medica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.133-141
- Anahtar Kelimeler: Microvascular angina, Inflammation, Dyslipidemias
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim. Microvascular inflammation is associated with cardiac syndrome X (CSX). High-density lipoprotein cholesterol (HDL-C) reveals antiatherogenic features with stimulating endothelial NO production, inhibiting oxidative stress and vascular inflammation. We investigated relationship between HDL-C and inflammatory markers in CSX. Methods. Hundred patients with CSX and control group of 80 subjects were evaluated. Hematologic indices, lipid levels and C-reactive protein (CRP) levels were studied in patients underwent coronary angiography. Results. CRP levels were higher in CSX group than control group (4.59±3.82 mg/dL vs. 2.48±1.32 mg/dL, P<0.001). HDL-C was significantly lower in CSX group compared to control group (36.5±4.0 mg/dL vs. 47.5±12.7 mg/dL, P=0.008). White blood cell (WBC) count was higher in CSX group than in control group. Neutrophil-lymphocyte ratio (NLR) was found significantly increased in CSX group as compared to control group. On multivariate linear regression, lower HDLC was found to be a significant predictor of higher NLR in patients with CSX independent from other clinical and biochemical variables. Conclusion. Lower HDL-C is associated with systemic inflammation in CSX. In patients with typical angina and normal epicardial coronaries,HDL-C and inflammatory markers should be investigated; one of the goals of treatment should be raising HDL-C.