The impact of enoxaparin on ovarian torsion–detorsion damage in rats
Acta Cirurgica Brasileira, cilt.41, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41
- Basım Tarihi: 2026
- Doi Numarası: 10.1590/acb414526
- Dergi Adı: Acta Cirurgica Brasileira
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Anahtar Kelimeler: Enoxaparin, Ischemia, Ovarian Torsion, Oxidative Stress, Reperfusion Injury
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: This study aimed to evaluate the protective effects of enoxaparin on ovarian tissue subjected to experimental ischemia/ reperfusion (I/R) injury in rats. Methods: Thirty female rats were divided into three groups: control, ischemia/reperfusion (I/R), and ischemia/reperfusion plus enoxaparin (I/R+E). Ovarian I/R injury was induced by 1 hour of ischemia followed by 1 hour of reperfusion. Rats in the I/R+E group received subcutaneous enoxaparin (0.5 mg/kg) prior to ischemia. Histopathological injury was assessed using a standardized scoring system, and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured. Results: Histopathological injury scores were significantly higher in the I/R group compared with controls (p < 0.05), with no significant difference between the I/R and I/R+E groups (p > 0.05). Biochemical analysis showed significantly higher TAS and lower OSI levels in the I/R+E group compared with the I/R group (p < 0.05), while TOS levels were comparable between groups. Conclusion: Although enoxaparin did not significantly improve histopathological injury, its beneficial effects on oxidative stress parameters suggest a protective role against oxidative stress in ovarian I/R injury.