Serum prohepcidin levels and iron parameters in term small-for gestational age newborns
Journal of Maternal-Fetal and Neonatal Medicine, cilt.24, sa.12, ss.1437-1439, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 12
- Basım Tarihi: 2011
- Doi Numarası: 10.3109/14767058.2011.581714
- Dergi Adı: Journal of Maternal-Fetal and Neonatal Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1437-1439
- Anahtar Kelimeler: Hypoxia, newborn, prohepcidin
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim. To understand the effect of prenatal chronic hypoxia on prohepcidin levels in term newborns. Method.We determined prohepcidin (Pro-Hep) levels in both term appropriate-for-gestational age (AGA) and term small-for-gestational- age (SGA) infants. Uteroplacental insufficiency had exposed all SGA infants to chronic hypoxia. Serum samples were collected from nine full-term SGA infants. Samples were analyzed for complete blood count, serum iron and ferritin concentrations, iron-binding capacity, and prohepcidin levels. Results.The mean serum Pro-Hep level was 156.4 ± 46.7 ng/ml for SGA infants and 482 ± 371.9 ng/ml for 16 healthy term AGA infants (historical controls); this difference was statistically significant. Statistical analyses revealed significant between-group differences for hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width, and serum ferritin and Pro-Hep levels. Conclusion. This study showed that compared with AGA infants, Pro-Hep levels were lower in term SGA infants, suggesting that prenatal chronic hypoxia decreases Pro-Hep synthesis. © 2011 Informa UK, Ltd.