Characteristics of tear meniscus, punctum, and cornea epithelium using an anterior segment optical coherence tomography in glaucoma
European Journal of Ophthalmology, cilt.35, sa.6, ss.2153-2162, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 6
- Basım Tarihi: 2025
- Doi Numarası: 10.1177/11206721251374170
- Dergi Adı: European Journal of Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.2153-2162
- Anahtar Kelimeler: Glaucoma, anterior segment optical coherence tomography, punctal diameter, tear meniscus height, central corneal epithelial thickness
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Purpose: To investigate the differences in punctal dimensions, tear meniscus height (TMH), and cornea epithelium among medically controlled glaucoma patients using anterior segment optical coherence tomography (AS-OCT) and evaluate the parameters that affect the results. Methods: This cross-sectional, observational study included 80 subjects with primary open-angle glaucoma and 80 normal subjects without glaucoma and ocular symptoms. AS-OCT was used to measure TMH, outer punctal diameter (OPD), punctal depth (PD), and central corneal epithelial thickness (CCET). Correlations for the effect of topical anti-glaucoma medications on OPD, PD, TMH, and CCET were analyzed. The impact of prostaglandin analogs (PGAs) and Beta-blockers on the parameters were evaluated. Results: No significant differences were found in age and sex between the groups (p = 0.333 and p = 0.635, respectively). Glaucoma patients exhibited significantly narrower OPD (p < 0.001), TMH (p < 0.001), and CCET (p = 0.006). Subjects on longer-duration therapy showed a statistically significant reduction in TMH and CCET (p < 0.001 and p = 0.022). While the PD value was significantly lower in those using anti-glaucoma medications containing Beta-blockers (p = 0.002), the TMH value was significantly lower in those containing PGAs (p = 0.037). Conclusions: Topical anti-glaucoma medications affect the OPD, TMH, and CCET in glaucoma patients compared with normal subjects. Topical anti-glaucoma medications usage duration has negative effects on TMH and CCET. Beta-blockers are more effective on the punctum, while PGAs are more effective on the TMH. These findings highlight the utility of AS-OCT in assessing asymptomatic glaucoma patients and its effects on the ocular surface.