The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels

Culha M. G., Atalay H. A., CANAT H. L., Alkan I., Ozbir S., Can O., ...Daha Fazla

Aging Male, cilt.23, sa.3, ss.173-178, 2020 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/13685538.2018.1459544
  • Dergi Adı: Aging Male
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Abstracts in Social Gerontology, AgeLine, CINAHL, EMBASE, MEDLINE, SportDiscus
  • Sayfa Sayıları: ss.173-178
  • Anahtar Kelimeler: Erectile dysfunction, 25-hydroxyvitamin D, mean platelet volume, inflammation, endothelial dysfunction
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: The aim of this study was to evaluate the relationship between mean platelet volume (MPV) and vitamin D levels according to ED severity. Methods: Between October 2015 and September 2017, patients who applied to the andrology outpatient clinic with an ED complaint were retrospectively reviewed. Patients with diabetes, hypertension, hyperlipidemia, malignancy, late-onset hypogonadism and smokers were not included in the study. The International Erectile Function Index-Erectile Function (IIEF-EF) questionnaire was used to assess the levels of erectile function. According to this scoring system, patients were divided into two groups. IIEF score: between 17 and 25 = mild ED (Group 1) and IIEF score between 16 and 0 = moderate–severe ED (Group 2). Blood samples of the patients were taken from antecubital vein and MPV and 25-hydroxyvitamin D [25(OH)D] levels were evaluated. Results: Ninety patients were included in the study (Group 1: n = 41, Group 2: n = 49). The mean age of the patients was 41.07 ± 8.56 and the mean body mass index (BMI) was 27.59 ± 3.91. 25(OH)D levels were found to be statistically lower in Group 2 (18.85 ± 6.09; 13.98 ± 7.10; p =.001). MPV levels were found to be statistically higher in Group 2 (10.05 ± 0.81; 10.78 ± 1.16; p =.001). Correlation between IIEF-EF scores and 25(OH)D levels was positive (p =.03, r = 0.22). There was negative correlation between IIEF-EF scores and MPV and between 25(OH)D levels and MPV levels [p =.003 for IIEF-EF/MPV, p =.04, r = −0.23 for 25(OH)D/MPV]. Conclusion: There is a significant positive correlation between ED severity and 25(OH)D levels and there is a significant negative correlation between ED severity and MPV levels.