Protective effects of curcumin on postoperative adhesions in rat models

Sarigoz T., SEVİM Y., Dirik H., Mutlu F., TOPUZ Ö., ERTAN T., ...Daha Fazla

Chirurgia (Turin), cilt.30, sa.6, ss.191-195, 2017 (Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.23736/s0394-9508.17.04660-5
  • Dergi Adı: Chirurgia (Turin)
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.191-195
  • Anahtar Kelimeler: Curcumin, Wound healing, Curcuma, Animal models
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

BACKGROUND: Curcumin is the main component of curry spices known as turmeric. Turmeric comes from the Zingiberaceae plant family and it is a traditional Chinese herb used for inflammatory conditions. It has gained popularity over the last decades and became the subject of scientific researches because of its anti-inflammatory and anti-oxidant activity. METHODS: The present study is an animal experimentation and designed as a pilot study. Twenty-four 5- to 6-week-old female Wistar albino rats weighing 150-250 g were used. They were randomized into 3 groups as sham, control and study groups each consisting of 8 rats. One percent dimethyl sulfoxide was administered intraperitoneally in control group, and in study group, curcumin powder was dissolved in 1% dimethyl sulfoxide and administered intraperitoneally at a dose of 200 mg/kg. Effects of curcumin on adhesion formation, and oxidative stress were evaluated. RESULTS: Macroscopic adhesion scores in sham and study groups were significant lower compared to control group (P<0.05). Vascular proliferation, fibroblastic activity, and inflammation scores were identified lower in sham group compared to control group (P<0.05). The oxidative status of the groups was investigated and lower TAS values were detected in sham group compared to control group (P<0.05). Additionally, TOS values were significantly low in the study group compared to control group (P<0.05). CONCLUSIONS: Curcumin seems reducing intra-abdominal adhesion formation significantly with dose-dependent anti-inflammatory, and antioxidant effects.