Successful ABO-incompatible liver transplantation with pre- and postoperative plasmapheresis, triple immunosuppression, and splenectomy for fulminant hepatic failure.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, cilt.3, sa.2, ss.390-393, 2005 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 3 Sayı: 2
- Basım Tarihi: 2005
- Dergi Adı: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.390-393
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Fulminant hepatic failure continues to be a challenge to hepatologists and surgeons. Because of the rapid deterioration in the clinical condition of patients with fulminant hepatic failure and the scarcity of available grafts, an ABO-incompatible liver donor may be the only choice for a patient with life-threatening hepatic insufficiency. Here, we report a patient with fulminant hepatic failure who received an ABO-incompatible liver transplantation who was treated with pre- and posttransplantation double-volume total plasma exchange, splenectomy, and triple immunosuppression (tacrolimus, mycophenolate mofetil, and prednisone) in July 2003. At 26 months' follow-up, the patient's postoperative course has been uneventful. Using protocols aimed at removing existing isohemagglutinins and reducing further antibody production, ABO-incompatible liver transplantation may be performed as a life-saving procedure in patients with fulminant hepatic failure.