Clinical importance of mean platelet volume in children diagnosed with Henoch-Schönlein purpura (Ig-A vasculitis) Henoch-Schönlein purpurası (IgA vasküliti) tanılı çocuklarda ortalama trombosit hacminin klinik önemi
Marmara Medical Journal, cilt.28, sa.3, ss.151-156, 2015 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 3
- Basım Tarihi: 2015
- Doi Numarası: 10.5472/mmjoa.2803.05
- Dergi Adı: Marmara Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.151-156
- Anahtar Kelimeler: Henoch-Schonlein Purpura, Ig-A Vasculitis, Mean platelet volume, Platelet count, Hematuria, Fecal occult blood
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Henoch-Schönlein purpura (HSP) or IgA vasculitis, is the most common form of childhood vasculitis. Mean platelet volume (MPV) is a parameter of a complete blood count that shows thrombocyte function and activation. This study evaluated the link between MPV and HSP. Patients and Methods: The data of 75 patients with a diagnosis of HSP were retrospectively evaluated. A control group was formed with 79 healthy children of similar gender and ages. Results: The average ages were 6.8±3.02 years (44 males, 31 females) and 7.49±2.95 years (40 males, 39 females) for the patient and control groups respectively. Mean platelet volume was found to be significantly lower in the study group (p<0.0001). Patients’ thrombocyte count were significantly higher (p<0.0001). Upon presentation 18 patients’ faecal occult blood (FOB) test results were positive, and there was microscopic hematuria in 12 patients, MPV was found to be significantly lower in FOB positive patients (p=0.043). Conclusion: Inflammation may affect MPV levels by increasing or decreasing. In our study, MPV measurements performed by a cheap and simple method, have been considered as a negative acute phase reactant. Decreased MPV measurements despite increased platelet count may be important in the prediction of hypercoagulopathy problems during the likely course of the disease and in close follow up for those with a predisposition.