The effect of vagotomy on bacterial translocation (An experimental study) VAGOTOMININ BAKTERIYEL TRANSLOKASYON UZERINE ETKILERI (DENEYSEL CALISMA)
Turkish Journal of Gastroenterology, cilt.8, sa.1, ss.82-88, 1997 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 1997
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.82-88
- Anahtar Kelimeler: Bacterial translocation, Vagotomy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The effects of truncal vagotomy and proximal vagotomy on bacterial translocation were searched on rats in this experiment. The rats were divided into three groups. Only esophageal and gastric manipulations were performed in control group. The anterior and posterior vagi were found and their 0.5-1 cm pieces were taken out in the truncal vagotomy + pyloric dilatation group in addition pyloric dilatation was performed by Fogarthy catheter. The branches of vagi which they give to rumene and corpus were first tighed by 5/0 silk then resected in the proximal gastric vagotomy group. All animals were sacrificed at 7th day. Qualitative and quantitative tissue cultures of cecum, liver, spleen, mesenteric lymph node were taken and a tissue sample from ileum was obtained for histopathological examination on light microscopy. At the end of microbiologic study, the bacterial concentration on cecal wall was 10.68 x 108 on truncal vagotomy group while it was 0.53 x 108 on proximal gastric vagotomy group. Bacterial translocation was observed more on vagotomy groups than control groups at mesenteric lymph node, liver and spleen. Bacterial translocation was more on truncal vagotomy group than proximal gastric vagotomy group (p < 0.05). Bacterial translocation was observed mostly in the liver, spleen, and mesenteric lymph node at proximal gastric vagotomy group. No microorganisms could be cultured on systemic blood cultures. Cultures were positive only in one rat in proximal gastric vagotomy group and in two rats in truncal vagotomy group. At the end of histopathologic examination, when histopathologic parametric points given for each rat were calculated, it was 5.44 ± (2.12) in truncal vagotomy group and 4.77 ± (2.12) in proximal gastric vagotomy group. The difference between these two groups was statistically significant (p < 0.05). Thus there was damage on intestinal wall on vagotomy groups and it was more on truncal vagotomy group than on proximal gastric vagotomy group. It was observed that bacterial translocation could occur after vagotomy. However, it did not cause bacteriemia. This translocation more frequently occurs after truncal vagotomy, than proximal gastric vagotomy.