MiR-205 and miR-200c: Predictive micro RNAs for lymph node metastasis in triple negative breast cancer
Journal of Breast Cancer, cilt.17, sa.2, ss.143-148, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 2
- Basım Tarihi: 2014
- Doi Numarası: 10.4048/jbc.2014.17.2.143
- Dergi Adı: Journal of Breast Cancer
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.143-148
- Anahtar Kelimeler: Breast, Carcinoma, micro RNAs
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: We examined expression profiles of 16 micro RNAs (miRNAs) in triple negative breast cancers to identify their potential as biomarkers for lymph node metastasis. Methods: The expression profiles of miR-9, miR-21, miR-30a, miR-30d, miR-31, miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a, miR-146b, miR-155, miR-181a, miR-200c, and miR-205 were examined by using real-time quantitative reverse transcription polymerase chain reaction in tumor samples and corresponding benign breast tissues. Their associations with histopathological features and prognostic parameters were assessed. Results: When compared with the expression in benign breast tissues, seven of the miRNAs (miR-31, miR-205, miR-34a, miR-146a, miR-125b, miR-34c, and miR-181a) were down regulated more than 1.5-fold in tumor tissues, whereas, only miR-21 was found to be unregulated more than 1.5-fold in tumor tissues. Although miR-200c levels were decreased only 1.12-fold in tumor tissues, the reduced expressions of miR-200c and miR-205 were significantly associated with lymph node metastasis (p= 0.021 and p= 0.016, respectively). Conclusion: Our results demonstrate that miR-205 and miR-200c expression levels may be useful in predicting lymph node metastasis in triple negative breast cancer patients. © 2014 Korean Breast Cancer Society. All rights reserved.