Propofol, Sevofluran ve Izofluranin perioperatif süreçte beyin kan akimi üzerine etkilerinin karşilaştirilmasi The effects of propofol, sevoflurane and isoflurane on cerebral blood flow velocity throughout perioperative period
Gulhane Medical Journal, cilt.58, sa.1, ss.48-55, 2016 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.5455/gulhane.214359
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.48-55
- Anahtar Kelimeler: Anesthetic agents, Hypocapnia, Transcranial doppler ultrasonography
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
This study is aimed to compare the effects of propofol, sevoflurane and isoflurane on cerebral blood flow velocity by using Transcranial Doppler ultrasonography throughout perioperative period. We enrolled 30 healty, male subjects for the study and randomized for three groups [propofol (n=10), sevoflurane group (n=10), isoflurane group (n=10)]. We measured flow velocity of right middle cerebral artery (VMCA), by using Transcranial Doppler ultrasonography from temporal bone window throughout perioperative period [preoperative, intraoperative (under normocapnic and hipocapnic conditions) and postoperative]. After induction of anesthesia using propofol (2mg/kg) and fentanyl (2 μg/kg), laryngeal mask airway was inserted and the anesthesia was maintained with either propofol infusion, or sevoflurane or isoflurane inhalation. There were no significant differences between preoperative and postoperative VMCA measurements for all the groups (p > 0,05). The VMCA values under normocapnic conditions were decreased significantly according to awake values in propofol group (p < 0,05). According to awake values Sevoflurane produced a little decrease, and isoflurane produced a little increase in VMCA under normocapnic conditions, but the difference was not found significant (p > 0,05). Under hipocapnic conditions, VMCA decreased significantly in all groups (p < 0,05). In conclusion, it seems to be safe using propofol as an anesthetic agent, especially in patients undergoing neurosurgical prosedure.