Successful Treatment of Macroglossia Due to Lymphatic Malformation with Sirolimus
Annals of Otology, Rhinology and Laryngology, cilt.124, sa.10, ss.820-823, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 124 Sayı: 10
- Basım Tarihi: 2015
- Doi Numarası: 10.1177/0003489415583330
- Dergi Adı: Annals of Otology, Rhinology and Laryngology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.820-823
- Anahtar Kelimeler: lymphatic malformation, macroglossia, sirolimus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation. Methods: Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m2 per dose, administered orally, twice daily at approximately 12-hour intervals. Results: After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved. Conclusion: This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.