Effect of therapeutic hypothermia on C-reactive protein levels in patients with perinatal asphyxia
American Journal of Perinatology, cilt.82, sa.2, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 82 Sayı: 2
- Basım Tarihi: 2014
- Doi Numarası: 10.1055/s-0034-1393933
- Dergi Adı: American Journal of Perinatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: asphyxia, hypothermia, sepsis, C-reactive protein
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective-To determine the changes in serum C-reactive protein (CRP) levels during therapeutic hypothermia. Study Design-Between January 2011 and June 2013, 133 hypoxic-ischemic encephalopathy patients being followed up in the neonatal intensive care unit of Dr. Sami Ulus Maternity and Children's Hospital are prospectively evaluated. Group 1; patients that received therapeutic hypothermia (n=74) and group 2; patients that did not required therapeutic hypothermia (n=59). All the patients underwent serial complete blood cell count and CRP assessments; blood cultures were obtained from all the cases at the time of admission and when CRP levels were elevated. Results-Positive blood cultures were encountered in five cases (6.7%) in group 1 while no blood culture-proven septicemia was encountered in group 2. The CRP levels elevated gradually reaching a peak level on the 4th day and then decreased during the therapeutic hypothermia in patients with no blood culture-proven septicemia in group 1. The CRP levels showed statistically significant changes reaching a peak level on the 7th day in patients with blood culture-proven septicemia in group 2. Also, the CRP levels showed no alteration with time in group 2. Conclusion-Therapeutic hypothermia itself might be associated with CRP elevation rather than an actual infection.