Circulating levels of IGF-I and IGFBP-3 in gastric cancer
Turkish Journal of Medical Sciences, cilt.42, sa.SUPPL.2, ss.1458-1462, 2012 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: SUPPL.2
- Basım Tarihi: 2012
- Doi Numarası: 10.3906/sag-1202-66
- Dergi Adı: Turkish Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1458-1462
- Anahtar Kelimeler: Insulin-like growth factors, insulin-like growth factor-1, stage, gastric cancer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To explore the causative mechanism of gastric carcinoma and to investigate the roles of circulating IGF-I and IGFBP-3 in gastric cancer. Materials and methods: Serum IGF-I and IGFBP-3 concentrations were measured using a 2-site coated tube immunoradiometric assay. Results: Serum IGF-I and IGFBP-3 values in gastric cancer patients were significantly lower compared to those in the control group. The difference between serum IGF-I/IGFBP-3 in patients and the control group was not significant. Conclusion: The low serum IGF-I and IGFBP-3 levels detected in patients with gastric cancer could be due to decreased synthesis or increased catabolism of IGF-I or both. It could be suggested that these parameters may be important in the development and prognosis of gastric cancer. © TÜBİTAK.