The relationship between plasma brain natriuretic peptide levels and left ventricular end-diastolic pressure and the extent of coronary artery involvement in chronic coronary artery disease Kronik koroner kalp hastaliǧinda serum beyin natriüretik peptid düzeyi ile sol ventrikül diyastol sonu basinci ve hastaliǧin derecesi arasindaki ilişki
Turk Kardiyoloji Dernegi Arsivi, cilt.34, sa.7, ss.413-418, 2006 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 7
- Basım Tarihi: 2006
- Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.413-418
- Anahtar Kelimeler: Biological markers/blood, Coronary angiography, Coronary disease, Natriuretic peptide, brain, Risk factors, Ventricular dysfunction, left
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Recent studies suggest that brain natriuretic peptide (BNP) is associated with the prognosis of coronary heart disease. We studied the relationship between BNP and left ventricular (LV) end-diastolic pressure and the number of involved coronary arteries in patients with chronic coronary artery disease. Study design: The study included 100 patients (30 women, 70 men; mean age 56 years; range 37 to 78 years) who underwent coronary angiography for definite or suspected coronary artery disease. Before angiography, baseline serum samples were obtained for plasma BNP, and LV end-diastolic pressure was measured. The patients were classified in three groups as normal (n=35), one-vessel disease (n=16) and multivessel disease (n=49). Results: The incidence of diabetes mellitus and the levels of BNP and fasting blood glucose were significantly higher, and LV end-diastolic pressure and the mean heart rate were significantly increased in multivessel disease. Vessel involvement was significantly correlated with BNP (r=0.463, p<0.001), LV end-diastolic pressure (r=0.745, p<0.001), and fasting blood glucose (r=0.235, p<0.05). Correlation between BNP and LV end-diastolic pressure was highly significant (r= 0.72, p<0.001). Multivariate linear regression analysis showed LV end-diastolic pressure as the only independent determinant of increased BNP levels (r=0.762, p<0.001). Conclusion: Increased plasma BNP levels are associated with increased LV end-diastolic pressure and increased vessel involvement in patients with chronic coronary artery disease.