Are all fixed dose combinations equally effective in blood pressure control? The analysis of four different fixed dose antihypertensive combinations
Pakistan Journal of Medical Sciences, cilt.28, sa.4, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 4
- Basım Tarihi: 2012
- Dergi Adı: Pakistan Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Fixed dose combination, Beta blocker, ACE inhibitor, Angiotensin receptor blocker, Calcium channel blocker, Diuretic
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Hypertension guidelines recommend the use of fixed dose combinations as the first step treatment in patients with stage 2 and 3 hypertension. The aim of this study was to compare the antihypertensive effects of four different fixed-dose preparations containing beta blocker (BB)-diuretic, ACE inhibitor (ACEI)-diuretic, angiotensin receptor blocker (ARB)-diuretic, and calcium channel blocker (CCB)-ACEI. Methodology: Eighty patients with newly diagnosed hypertension whose sitting blood pressure (BP) ≥ 160/100 mmHg were randomized to receive either of those four fixed dose antihypertensive preparations: atenolol 50 mg-hydrochlorotiazide (HCTZ) 12.5 mg, or lisinopril 20 mg-HCTZ 12.5 mg, or telmisartan 80 mg-HCTZ 12.5 mg or verapamil 180 mg- trandolapril 2 mg. All the patients were followed up for six months. Results: Both systolic BP (SBP) and diastolic BP (DBP) were reduced similarly in all groups (45.7/22.4 mmHg in BB-diuretic group, 45.8/18.1 mmHg in ACEI-diuretic group, 54.6/17.6 mmHg in ARB-diuretic group and 38.9/16 mmHg in ACEI-CCB group. For SBP p=0.19 and for DBP p=0.43). Conclusion: All investigated fixed dose antihypertensive combinations were found similarly effective in reducing blood pressure.