Evaluation of corneal and anterior segment parameters in pediatric phenylketonuria
Japanese Journal of Ophthalmology, cilt.70, sa.2, ss.238-244, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 70 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s10384-025-01283-3
- Dergi Adı: Japanese Journal of Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.238-244
- Anahtar Kelimeler: Phenylketonuria, Corneal topography, Corneal specular microscopy, Cornea endothelium
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To compare anterior segment parameters in healthy children of the same age with those in children with phenylketonuria (PKU). Study design: Retrospective observational study Methods: Data from 25 eyes of PKU patients (study group) and 60 eyes of age- and gender-matched children (control group) were analyzed. The records reviewed included results from a comprehensive ophthalmic evaluation that each participant had previously undergone. This evaluation included refraction evaluation (spherical equivalent), best corrected visual acuity (BCVA) testing, slit-lamp biomicroscopy, fundus examination, intraocular pressure (IOP) measurement, specular microscopy, and corneal topography measurement. Result: Forty-five (52.9%) age- and sex-matched participants were girls and 40 (47.1%) were boys. The percentage of hexagonal cells (HEX) was 65.53±8.17 in the study group and 69.75±4.19 in the control group (p=0.021). Flat keratometry (K1) was 41.70±1.54 D in the study group and 43.16±1.52 D in the control group (p=0.002). Steep keratometry (K2) was 42.55±1.83 D in the study group and 43.91±1.73 D in the control group (p=0.013). Conclusion: This study shows that patients with pediatric PKU have differences in the anterior segment parameters, including keratometric values and HEX, when compared with healthy controls.