Prognostic risk factors for rare oncocytic variant in 101 cases of papillary thyroid carcioma
Hellenic Journal of Nuclear Medicine, cilt.22, sa.2, ss.116-122, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 2
- Basım Tarihi: 2019
- Dergi Adı: Hellenic Journal of Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.116-122
- Anahtar Kelimeler: Metastasis, Oncocytic variant, Papillary thyroid cancer, Predeined risk factors, Recurrence
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Oncocytic variant (OV) is an unusual subtype of papillary thyroid cancer whose histopathologic diagnostic criteria, clinicopathologic features and biological behavior are different and have not been comprehens ively studied, characterized in literature. Previous studies present conficting results upon its prognos is. We investigated demographic and clinicopathologic risk factors affecting its prognosis while present ing our clinical experience. Subjects and Methods: This is a retrospective cohort study reviewing 101 pati- ents of OV from an archive of 4500 well-differentiated thyroid cancer patients treated with iodine-131 (131I) between 1991 and 2017. Predeined parameters of age, gender, tumor size (TS), total131I dose, time to recurrent disease, overall survival, extrathyroidal extension, multifocality, vascular invasion, accompanying other variants, capsular status of thyroid gland, initial cervical lymph node (LN) metastases, preablation stimulated thyroglobulin level, background thyroiditis and stage were evaluated by statistical comparison between metastatic and nonmetastatic groups. Results: Seventeen cases (17%) developed metastases/ recurrence, 70% of the recurrences occured before 24 months. Four patients (4%) died during the follow-up. Metastat ic sites were usually cervical LN, local recurrence in thyroid bed and lungs. Multivariate analysis revealed stage (IV) and TS were the main parameters impacting recurrence/metastases. In the follow-up, isolated cervical LN metastases were found in 41% of metastatic cases, while 12% had sole recurrence in thyroid bed. Eighty eight percent of the metastatic disease included locoregional (cervical) and/or remote LN. The recurrences were associated with initial thyroid masses greater than 3.5cm in diameter. Conclusion: We found that the prognosis of OV is not poor in our series. Stage (IV) and tumor size are the main risk factors in metastatic development.