Stress response in vertebra surgery by total intravenous and inhalation anaesthesia
International Journal of Clinical Practice, cilt.75, sa.10, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 75 Sayı: 10
- Basım Tarihi: 2021
- Doi Numarası: 10.1111/ijcp.14602
- Dergi Adı: International Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We compared inhalational and total intravenous anaesthesia about haemodynamic stability and oxidative stress response in vertebral surgery. Backgrounds and Methods: Fifty-nine elective vertebral surgery patients were randomly divided into propofol (Group P) and desflurane (Group D) groups. Intraoperative haemodynamic parameters, preoperative and post-operative native thiol, total thiol, disulfide, C-reactive protein (CRP), albumin, cortisol and catalase levels were studied. Results: Post-operative native thiol and total thiol values in Group P were higher (P =.044 and P =.031). Post-operative albumin value in Group P was lower than the preoperative value (P <.001). The post-operative CRP and albumin values in Group D were lower than the preoperative value. The cortisol value was high (P =.03, P <.001 and P <.001). The post-operative albumin value in Group P was higher (P =.03). There is a positive correlation between CRP and disulfide values (P =.017), between albumin and native thiol values (P <.001), between total thiol value (P <.001), between the cortisol value and the disulfide/native thiol value (P =.002) and between native/total thiol value (P =.003) and a negative correlation between disulfide/native thiol value (P =.005), between disulfide/total thiol value (P =.003) and between the native/total thiol value (P =.001). Conclusion: Dynamic thiol/disulfide haemostasis reflects oxidative stress. Propofol positively contributes to oxidative stress in elective vertebral surgery.